Orale hochdosierte Gestagentherapie als Versagerschema beim metastasierten Mammakarzinom
- 1 January 1984
- journal article
- abstracts
- Published by Georg Thieme Verlag KG in Deutsche Medizinische Wochenschrift (1946)
- Vol. 109 (02) , 46-49
- https://doi.org/10.1055/s-2008-1069136
Abstract
High-dosage medroxyprogesterone (Farlutal, 1 g/d orally) was administered to 42 female patients with progressive disseminated carcinomas of the breast after conventional cytostatic and hormonal treatment had failed. Besides evaluation of success of treatment the pharmacokinetics of medroxyprogesterone were investigated. A remission rate of 37% (total and partial remissions) indicated that high-dosage oral treatment with gestagens can be used as "failure-regime" in patients at the end of conventional treatment. The plasma level of the gestagen approached values corresponding to high-dosage intramuscular application.Keywords
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