Prostacyclin derivatives prevent the fibrotic response to TGFβ2 by inhibiting the Ras/MEK/ERK pathway
Open Access
- 4 October 2002
- journal article
- fj express-summaries
- Published by Wiley in The FASEB Journal
- Vol. 16 (14) , 1949-1951
- https://doi.org/10.1096/fj.02-0204fje
Abstract
The SMAD-mediated induction of connective tissue growth factor (CTGF), a fibroproliferative cytokine, by transforming growth factor (TGF)β is required for the development of sustained fibrosis in hum...Keywords
Funding Information
- National Institutes of Health (AR45879)
This publication has 39 references indexed in Scilit:
- The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblastsMolecular Pathology, 2001
- Ski/Sno and TGF-β signalingCytokine & Growth Factor Reviews, 2001
- Role of Transforming Growth Factor β in Human DiseaseNew England Journal of Medicine, 2000
- Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated TranscriptionJournal of Biological Chemistry, 1999
- The Connective Tissue Growth Factor/Cysteine- Rich 61/Nephroblastoma Overexpressed (CCN) FamilyEndocrine Reviews, 1999
- CYCLIC AMP SIGNALING AND GENE REGULATIONAnnual Review of Nutrition, 1998
- Protein kinases — structure and functionFEBS Letters, 1995
- Mechanism of activation of the TGF-β receptorNature, 1994
- In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds.Journal of Clinical Investigation, 1993
- Modified Elastic Tissue-Masson Trichrome StainStain Technology, 1984