Design syntheses and mitochondrial complex I inhibitory activity of novel acetogenin mimics
Open Access
- 1 May 2000
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 267 (9) , 2538-2546
- https://doi.org/10.1046/j.1432-1327.2000.01263.x
Abstract
Some natural acetogenins are the most potent inhibitors of mitochondrial complex I. These compounds are characterized by two functional units [i.e. hydroxylated tetrahydrofuran (THF) and α,β‐unsatura...Keywords
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