Prostaglandin Forming Cyclooxygenase Activity in Rabbit Amnion, Yolksac Splanchnopleure, Placenta, Decidua, and Uterus at 20 to 30 Days Gestation

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Abstract
Prostaglandin forming cyclooxygenase was quantified using an O2-uptake assay in 5 tissues during the last trimester in pregnant rabbits. At day 20 of pregnancy, cyclooxygenase activity was 7-fold greater in the placenta (147-204 U/g) than in the amnion, splachnopleure, decidua or uterus. Cyclooxygenase activity increased during gestation (P < 0.03); the major change in activity occurred in the amnion (from 6 U/g at 20 days to 228 U/g on day 30; P < 0.01). Prostaglandin synthesis evidently increases near the time of parturition.