THE QUANTITATIVE RELATIONSHIP BETWEEN IMMUNE SERUM AND INFECTIVE DOSE OF PARASITES AS DEMONSTRATED BY THE PROTECTION TEST IN MONKEY MALARIA

Abstract
The minimal infective dose of Plasmodium knowlesi for rhesus monkeys was found in this study to be between 1 and 10 parasites when injected intraperitoneally. As the dose of parasites is increased, the length of time prior to the appearance of circulating parasites is decreased. However, the severity of the infection once it is established is independent of the initial dose of parasites.

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