Antiangiogenic Activity of Tumor Necrosis Factor-.ALPHA. Production Regulators Derived from Thalidomide.
Open Access
- 1 January 1999
- journal article
- Published by Pharmaceutical Society of Japan in Biological & Pharmaceutical Bulletin
- Vol. 22 (2) , 224-226
- https://doi.org/10.1248/bpb.22.224
Abstract
Recently, we developed novel tumor necrosis factor (TNF)-α production regulators with a phthalimide skeleton derived fromthalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.Keywords
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