T cell antigen receptor immune complexes demonstrating biologic and proteolytic activity
- 1 January 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in International Immunology
- Vol. 5 (1) , 79-88
- https://doi.org/10.1093/intimm/5.1.79
Abstract
An elastase-like protease, recently recognized as a specific product of murine T cells, may functionally associate with the classical TCR. T cell elastase, found in combination with the natural elastase inhibitor α1-antitrypsin (α1-protease inhibitor, α1PI), is produced by both CD4+ and CD8+ T lymphocytes. T cell elastase and α1-PI are found chemically associated with the TCR in an antigen-specific complex reminiscent of the Ig-complement ‘Immune complexes’.Keywords
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