Antitrypanosomal Activities of Proteasome Inhibitors
Open Access
- 1 June 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (6) , 2038-2040
- https://doi.org/10.1128/aac.46.6.2038-2040.2002
Abstract
Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development.Keywords
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