Coping and Immunosuppression: Inescapable But Not Escapable Shock Suppresses Lymphocyte Proliferation
- 5 August 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4610) , 568-570
- https://doi.org/10.1126/science.6603018
Abstract
Rats were given series of escapable shocks, identical inescapable shocks, or no shock. The subjects were reexposed to a small amount of shock 24 hours later, after which an in vitro measure of the cellular immune response was examined. Lymphocyte proliferation in response to the mitogens phytohemagglutinin and concanavalin A was suppressed in the inescapable shock group but not in the escapable shock group. This suggests that the controllability of stressors is critical in modulating immune functioning.This publication has 27 references indexed in Scilit:
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