Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.
Open Access
- 1 February 1987
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 7 (2) , 932-935
- https://doi.org/10.1128/mcb.7.2.932
Abstract
An activated K-ras oncogene was detected by transfection in NIH 3T3 cells and by Southern blot analysis in 6 of 12 rat skin tumors induced by ionizing radiation. The DNA from 10 of the 12 tumors also showed c-myc gene amplification and restriction polymorphisms. Evidence for tissue specificity was observed in patterns of oncogene activation, with each of three clear cell carcinomas exhibiting activation of both c-myc and K-ras oncogenes.This publication has 37 references indexed in Scilit:
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