THE METABOLISM OF FREE FATTY ACIDS AND CHYLOMICRON TRIGLYCERIDES BY THE PERFUSED CHOLINE‐DEFICIENT RAT'S LIVER

Publisher Website
Google Scholar
Abstract
Experiments were carried out with isolated perfused livers from cholinedeficient rats to study the uptake and metabolism of free 14C‐palmitic acid and 14C‐labelled chylomicron triglycerides. The livers from choline‐deficient rats took up both these forms of fat from the perfusate as rapidly as did normal livers. There was no significant difference in the amount of radioactivity recovered from the liver lipids in choline‐deficient and normal livers but there was a significantly higher incorporation of labelled fatty acids into the noncholine‐containing phosphatides in the choline‐deficient livers. Both normal and choline‐deficient livers retransported labelled fatty acids into the perfusate as esterified fat. There was a lower incorporation into perfusate triglycerides and a higher incorporation into perfusate phospholipids in choline‐deficient livers. In both groups of experiments, some free fatty acids were also released into the perfusate from the liver. The oxidation of both free fatty acids and chylomicron triglycerides occurred readily in choline‐deficient livers. The specific activity of the CO2 produced by choline‐deficient livers from fed rats was significantly higher than that produced by livers from fed normal rats.

This publication has 0 references indexed in Scilit: