Human brain fluoxetine concentrations
- 1 August 1993
- journal article
- research article
- Published by American Psychiatric Association Publishing in The Journal of Neuropsychiatry and Clinical Neurosciences
- Vol. 5 (3) , 322-329
- https://doi.org/10.1176/jnp.5.3.322
Abstract
Data on 22 subjects treated with fluoxetine suggest that magnetic resonance spectroscopy (MRS) of fluorine-19 can measure brain concentrations of fluoxetine/norfluoxetine in vivo. Fluoxetine accumulates in the human brain relative to plasma, with brain concentrations of fluoxetine/norfluoxetine ranging up to 10.7 micrograms/ml. Brain concentrations may reach a plateau between 6 and 8 months of treatment. The apparent concentration in brain relative to plasma is 20:1, roughly parallel to brain antidepressant concentration ratios in animal studies.Keywords
This publication has 11 references indexed in Scilit:
- Sensitive and Selective Liquid-Chromatographic Assay of Fluoxetine and Norfluoxetine in Plasma with Fluorescence Detection After Precolumn DerivatizationClinical Chemistry, 1992
- Fluoxetine and trifluoperazine in human brain: A 19F-nuclear magnetic resonance spectroscopy studyPsychiatry Research: Neuroimaging, 1992
- Detection of psychoactive drugs in vivo in humans using 19F NMR spectroscopyBiological Psychiatry, 1991
- One-dimensional chemical shift imaging of fluorinated neuroleptics in rat brain in vivo by 19F NMR rotating frame zeugmatographyMagnetic Resonance Imaging, 1989
- 19F magnetic resonance imaging and spectroscopy of a fluorinated neuroleptic ligand: In vivo and in vitro studiesPsychiatry Research, 1988
- FluorinePublished by Springer Nature ,1987
- Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in miceProgress in Neuro-Psychopharmacology and Biological Psychiatry, 1987
- Fluorinated psychopharmacological agents: Noninvasive observation by flourine-19 nuclear magnetic resonancePsychiatry Research, 1986
- Brain concentrations of tricyclic antidepressants: Single-dose kinetics and relationship to plasma concentrations in chronically dosed ratsPsychopharmacology, 1982
- Cerebral pharmacokinetics of imipramine in rats after single and multiple dosagesNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1981