Congeners of etamycin produced by Streptomyces griseoviridus.
- 1 January 1979
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 32 (4) , 392-401
- https://doi.org/10.7164/antibiotics.32.392
Abstract
S. griseoviridus produces, in addition to etamycin, several related compounds which can be separated by partition chromatography. One of these was characterized by amino acid analysis and mass spectrometry and shown to have the same structure as etamycin, except for replacement of the hydroxyproline residue by proline. Evidence was obtained for additional congeners similarly related to etamycin by amino acid exchange. The relative proportions of such congeners produced by S. griseoviridus depends upon the medium in which the culture is grown. Certain amino acids support good yields of the metabolites, and the culture appears to be steered towards the synthesis of congeners containing such amino acids.This publication has 2 references indexed in Scilit:
- High resolution and field desorption mass spectrometry studies and revised structures of alamethicins I and IIJournal of the American Chemical Society, 1977
- PHOTOMETRIC NINHYDRIN METHOD FOR USE IN THE CHROMATOGRAPHY OF AMINO ACIDSJournal of Biological Chemistry, 1948