Immunologically Specific Retention of Long-Lived Lymphoid Cells in Antigenically Stimulated Lymph Nodes

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Abstract
The lymphoid cells selectively retained in lymph nodes that have been stimulated by xenogenic erythrocytes include cells of the long-lived subpopulation. This selective retention appears to be real and not an artifact resulting from the reutilization of radioactively labeled DNA or its split products. Lymph nodes draining skin allografts also show a selective retention of long-lived lymphoid cells, although this retention is of a lesser magnitude and occurs at a somewhat slower rate. While most of this selective retention is related to factors other than the immunologic specificity of the long-lived cells involved, we have demonstrated that a small portion of it reflects the accumulation of specific memory cells. This has been done by using an experimental design based on: a) the adoptive immunization of mice to two different antigens (BALB/c mice immunized to DBA/2 and C57BL/Ks histocompatibility antigens), b) the labeling of long-lived lymphocytes of the donor mice with either 3H-thymidine or 14C-thymidine following immunization, and c) the simultaneous counting of both radioisotopes in each set of stimulated lymph nodes.

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