A Swedish family with abnormal antithrombin III
- 1 May 1985
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 34 (5) , 412-416
- https://doi.org/10.1111/j.1600-0609.1985.tb00770.x
Abstract
An abnormal variant of antithrombin III is reported in a young male with deep vein thrombosis. The heparin cofactor, progressive thrombin inhibition, and factor Xa inactivation are decreased. The abnormality seems to be a mutation which is transmitted in an autosomaldominant way. The half-life and fractional catabolic rate of 125I antithrombin III concentrate is the same in this patient as in patients with the classic type of antithrombin III deficiency and in a control.Keywords
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