CHORIONEPITHELIOMA

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Abstract
While the mechanism and the underlying nature of the increased excretion of the gonadotropic substances during pregnancy are still unsettled problems, the clinical value of the Aschheim-Zondek reaction for the diagnosis of both normal and pathologic pregnancy is well established.1Before this biologic test for living chorionic villi was discovered, the diagnosis of early chorionepithelioma was difficult or impossible. Bleeding following labor or molar pregnancy is the usual clinical sign pointing to the possibility of chorionepithelioma; however, the bleeding in early cases may not be associated with tumor formation or diagnostic curettings. Most cases of chorionepithelioma prior to the utilization of the Aschheim-Zondek test were not diagnosed until a uterine mass was palpable, until a curettage brought forth characteristic tissue, or until metastases in the lungs or vagina appeared. Often a mass was not palpated until metastases had already occurred. Curettage as a diagnostic method not only is uncertain

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