IMMUNODEFICIENCY IN DOWNS-SYNDROME - LYMPHOCYTE-T SUBSET IMBALANCE IN TRISOMIC CHILDREN
- 1 January 1978
- journal article
- research article
- Vol. 33 (2) , 298-301
Abstract
In 14 children with Down''s syndrome the percentage of circulating T[thymus-derived]-cells forming rosettes with sheep erythrocytes, either in the presence or in the absence of fetal calf serum, was significantly lower than in matched controls. The percentage of T-cells forming rosettes with human erythrocytes was significantly higher in children with Down''s syndrome than in controls. A defective T-cell maturation may be an early integral feature of Down''s syndrome.This publication has 16 references indexed in Scilit:
- T-LYMPHOCYTE DEFICIENCY IN DOWN SYNDROMEThe Lancet, 1977
- STRESS DEFICIENCY OF THE T-LYMPHOCYTE SYSTEM EXEMPLIFIED BY DOWN SYNDROMEThe Lancet, 1977
- Clinical, Immunological and Histopathological Evidence for Thymic Deficiency in Down’s Syndrome (Mongolism)Published by Springer Nature ,1976
- Derangements of immunoglobulin levels, phytohemagglutinin responsiveness and T and B cell markers in Down's syndrome at different agesEuropean Journal of Immunology, 1975
- MORTALITY AND LIFE‐TABLE IN DOWN'S SYNDROMEActa Paediatrica, 1975
- Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromideClinical Immunology and Immunopathology, 1975
- The Human Rosette-Forming Cell as a Marker of a Population of Thymus-Derived CellsJournal of Clinical Investigation, 1972
- MONGOLISM AND THYROID AUTOIMMUNITYThe Lancet, 1965
- LYSOSOMES IN DIVIDING CELLS, WITH SPECIAL REFERENCE TO LYMPHOCYTESThe Lancet, 1964