The effect of amperozide on uptake and release of [3H]‐dopamine in vitro from perfused rat striatal and limbic brain areas

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Abstract
Amperozide, a putatively antipsychotic drug, was studied for its effects on uptake and release of [3H]‐dopamine in rat brainin vitro.Amperozide inhibited uptake of [3H]‐dopamine in striatal chopped tissuein vitrowith an IC50of 18 μM. It also increased basal release of [3H]‐dopamine from perfused rat striatal and limbic tissuein vitroat concentrations above 5 μM. Release of [3H]‐dopamine from perfused rat striatal and limbic tissue stimulated with 5 μM amphetamine, was inhibited by 1 μM amperozide to 46%. No significant difference was found for the effect of amperozide onin vitrorelease of [3H]‐dopamine from corpus striatum compared to tissue from limbic brain regions; neither on basal release nor on amphetamine‐stimulated release of dopamine.