Intracellular Localization of Human Plasma Proteins Revealed by Peroxidase-labeled Antibody Method in Human Tumors Transplanted in Nude Mice

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Abstract
The intracellular localization of plasma proteins in human tumors transplanted in nude mice was investigated by immuno-electron microscopic method. Human plasma proteins produced by malignant tumors were also confirmed by immunochemical analysis of blood plasma of tumor-bearing mice. In general, human plasma proteins of adult type such as albumin, α1-antitrypsin and transferrin were localized in the membrane system of endoplasmic reticula and Golgi complex. Albumin and transferrin were demonstrated also on the surface of microvilli of certain tumor cells but not on the basal cytoplasmlc membrane. On the other hand, α-fetoprotcln was localized on ribosomes as well as in endoplasmic reticula and Golgi complex.