POSITIVE REGULATION OF HUMAN THYROTROPIN RECEPTOR mRNA BY THYROTROPIN
- 1 June 1991
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 72 (6) , 1394-1396
- https://doi.org/10.1210/jcem-72-6-1394
Abstract
We have assessed the influence of natural and recombinant thyrotropin (TSH) on mRNA specific for the human TSH receptor (TSHR) in normal and abnormal adult human thyroid monolayer cells. Using physiological concentrations of TSH (1000% increase after 24 hours exposure. At high TSH concentrations (>1000 mU/L), this increase in TSHR-specific mRNA was markedly reduced. However, at no time were basal TSHR mRNA levels suppressed even with 100 U/L of TSH for 48 hours. These observations demonstrate ligand-induced up-regulation of the human TSHR mRNA by physiologically relevant concentrations of TSH.Keywords
This publication has 0 references indexed in Scilit: