Drugs derived from cannabinoids. 3. Sulfur analogs, thiopyranobenzopyrans and thienobenzopyrans

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Abstract
S analogs of cannabinoids were prepared utilizing the Pechmann condensation between the appropriate keto ester and 5-(1,2-dimethylheptyl)resorcinol, followed by Grignard reaction. Compounds of various structural types, which had different ring size and position of the S atom substituted in the alicyclic ring, were active CNS agents in pharmacological tests in mice, rats and dogs. They showed profiles qualitatively similar to those of the nitrogen and carbocyclic analogs. Basic esters of the most interesting parent phenols were also prepared and tested.

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