Pharmacokinetics and Toxicity Testing
- 1 January 1984
- journal article
- review article
- Published by Taylor & Francis in CRC Critical Reviews in Toxicology
- Vol. 12 (4) , 343-385
- https://doi.org/10.3109/10408448409044214
Abstract
The pharmacokinetic basis for the design of toxicity tests is discussed with reference to the absorption and clearance of drugs. The absorption and clearance of a wide range of drugs by laboratory animals and man has been examined and reviewed to provide a firm basis against which new drugs can be compared. Some pitfalls in either the empirical approach to toxicology or the incorrect interpretation of kinetic data are highlighted. An approach is outlined for the rational application of animal pharmacokinetic data in the assessment of the safety in man of a new therapeutic agent.Keywords
This publication has 96 references indexed in Scilit:
- Enteric transport of chlordecone (Kepone®) in the ratJournal of Pharmacokinetics and Biopharmaceutics, 1981
- Hepatic clearance of local anesthetics in manJournal of Pharmacokinetics and Biopharmaceutics, 1977
- Biological effects of furosemide in relation to its disposition in rabbits.CHEMICAL & PHARMACEUTICAL BULLETIN, 1977
- Gastric emptying rate constants after oral administration of drug solution to mice, rats, and rabbits.CHEMICAL & PHARMACEUTICAL BULLETIN, 1977
- Altered Hepatic Blood Flow and Drug Disposition1Clinical Pharmacokinetics, 1976
- Rates of choleresis in various speciesDigestive Diseases and Sciences, 1976
- The effects of some pharmacologically active amines on the rate of gastric emptying in ratsLife Sciences, 1976
- Animal scale-upJournal of Pharmacokinetics and Biopharmaceutics, 1973
- Regional hemodynamic effects of beta-adrenergic blockade with propranolol in the unanesthetized primateAmerican Heart Journal, 1973
- Complication in Using Rabbits for the Study of Oral Drug AbsorptionCHEMICAL & PHARMACEUTICAL BULLETIN, 1969