Abstract
Rats in which cortical spreading depression (SD) was induced immediately after learning of a passive avoidance task showed a retention deficit relative either to Ss not given SD, or to pain-control Ss. The hypothesis that the retention deficits resulting from SD are due to the spread of the SD to subcortical structures was not supported. The retention deficit following SD was still present in Ss that had bilateral slits in their temporal cortex, although such slits probably hinder the subcortical spread of SD.

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