Hippocampal Volume in Patients With Alcohol Dependence
Open Access
- 1 April 1999
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 56 (4) , 356-363
- https://doi.org/10.1001/archpsyc.56.4.356
Abstract
IN PATIENTS with chronic alcoholism, brain volumes and brain weight are decreased.1,2 Postmortem investigations show reduced white matter3 as well as decreased neuronal density of the cortical gray matter4 with selective neuronal loss in the superior frontal cortex.4-6 Heavy drinking accelerates age-related myelin loss.7 Neuronal loss in all hippocampal ammonic fields and the gyrus dentate has been reported.8 Other investigators have found reductions of the hippocampal white matter only.6Keywords
This publication has 39 references indexed in Scilit:
- The cerebral cortex is damaged in chronic alcoholicsNeuroscience, 1997
- Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary reportPublished by Elsevier ,1997
- Hippocampal volume in women victimized by childhood sexual abusePsychological Medicine, 1997
- Why Stress Is Bad for Your BrainScience, 1996
- Alcohol, Corticosteroids, Energy Utilization, and Hippocampal EndangermentAnnals of the New York Academy of Sciences, 1995
- Neuroimaging in alcoholism: CT and MRI results and clinical correlatesJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1995
- Do alcoholics drink their neurons away?The Lancet, 1993
- Effects of aging and alcohol on the biochemical composition of histologically normal human brainMetabolic Brain Disease, 1988
- Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for agingJournal of Neuroscience, 1985
- Brain weights in alcoholics.Journal of Neurology, Neurosurgery & Psychiatry, 1982