EPIDERMAL GROWTH-FACTOR, RENIN, AND PEPTIDASE IN CULTURED TUMOR-CELLS OF SUB-MANDIBULAR GLAND ORIGIN

  • 1 January 1980
    • journal article
    • research article
    • Vol. 42  (6) , 656-662
Abstract
Dimethylbenz[a]anthracene was injected into the submandibular glands of male Swiss-Webster mice. From tumors obtained, 3 cell lines were established. Immunocytochemical stainings revealed epidermal growth factor, renin and peptidase in a significant portion of cultured tumor cells. In addition, the presence of epidermal growth factor was demonstrated by radioimmunoassays. Since epidermal growth factor, renin and peptidase are localized in the granular convoluted tubules in mouse submandibular gland, the granular convoluted tubules in mouse submandibular gland, the granular convoluted tubule cells apparently are the targets of chemical carcinogens.