PHYTOESTROGENS AND THEIR ANTAGONISM TO PROGESTERONE AND TESTOSTERONE

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Abstract
The oestrogenic effect of Glycyrrhiza glabra extract and Pimpinella anisum oil was tested in ovariectomized mice and rats by the vaginal smear technique, and in immature rabbits or ovariectomized rats by the uterine weight method. For the first procedure the animals were injected in the morning and evening of 2 consecutive days. Four smears were taken: the first in the evening of the day after the last injection, the second and third in the morning and evening of the day after, and the fourth in the morning of the following day. Smears were regarded as positive when epithelial cornification and a decrease in the number of leucocytes could be demonstrated. The oestrogenic effect of these substances on the vagina was compared with that of a standard dose of oestradiol. The results were evaluated by the methods of Robson (1938a, b). To examine the effect on uterine development, immature and

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