Effect of topical calcipotriol on congenital ichthyoses
- 1 October 1994
- journal article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 131 (4) , 546-550
- https://doi.org/10.1111/j.1365-2133.1994.tb08558.x
Abstract
We investigated the clinical efficacy of topically applied calcipotriol in six patients with congenital ichthyosis, using a double-blind, bilaterally paired, comparative approach. Unilateral improvement, in favour of the calcipotriol-treated side, was observed in three patients with lamellar ichthyosis. A beneficial response was also observed in a patient with bullous ichthyotic erythroderma of Brocq. No clinical side-effects or laboratory anomalies were observed. This study indicates that calcipotriol constitutes a new and promising approach in alleviating disorders of keratinization characterized by hyperproliferation, other than psoriasis.Keywords
This publication has 14 references indexed in Scilit:
- 1α,25‐(OH)2D3 Use on Psoriasis and IchthyosisInternational Journal of Dermatology, 1991
- Treatment of Psoriasis by the Topical Application of the Novel Cholecalciferol Analogue Calcipotriol (MC 903)Archives of Dermatology, 1989
- The Sjögren-Larsson SyndromePublished by Springer Nature ,1989
- A novel approach for the evaluation and treatment of psoriasis: Oral or topical use of 1,25-dihydroxyvitamin D3 can be a safe and effective therapy for psoriasisJournal of the American Academy of Dermatology, 1988
- Effects of a novel vitamin D analogue MC 903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivoBiochemical Pharmacology, 1988
- Skin as the Site of Vitamin D Synthesis and Target Tissue for 1,25-Dihydroxyvitamin D3Archives of Dermatology, 1987
- Effect of 1α,25-Dihydroxyvitamin D3 on the Morphologic and Biochemical Differentiation of Cultured Human Epidermal Keratinocytes Grown in Serum-Free ConditionsJournal of Investigative Dermatology, 1986
- Regulation of Terminal Differentiation of Cultured Mouse Epidermal Cells by lα,25-Dihydroxyvitamin D3*Endocrinology, 1983
- Interaction of 1,25-Dihydroxyvitamin-D3with Keratinocytes and Fibroblasts from Skin of Normal Subjects and a Subject with Vitamin-D-Dependent Rickets, Type II: A Model for Study of the Mode of Action of 1,25-Dihydroxyvitamin D3*Journal of Clinical Endocrinology & Metabolism, 1983
- Author IndexJournal of Investigative Dermatology, 1966