MINERAL CONTENT OF THE BRAIN
- 1 March 1940
- journal article
- other
- Published by American Medical Association (AMA) in Archives of Neurology & Psychiatry
- Vol. 43 (3) , 463-471
- https://doi.org/10.1001/archneurpsyc.1940.02280030037004
Abstract
The pathologic changes produced by excessive amounts of insulin have been studied extensively by many authors. In man, Wohlwill,1Doering,2Terplan3and others described lesions in the cerebral neurons following hyperinsulinism. Stief and Tokay,4Schmid5and Weil and we6demonstrated the damaging action of insulin on the central nervous system in experimental animals. Reports in the literature of damage to the brain following the administration of metrazol are still scarce. Strecker and his associates7and Stender8studied the changes occurring after large doses of metrazol in experimental animals. Weil and one of us (E. L.)9reported pathologic alterations in brains of rabbits following injection of metrazol over a long period. According to most authors, there seems to be no doubt that large doses of insulin or metrazol injected over a long period produce severe irreversible changes in the central nervous system.Keywords
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