Effects of geniposide isolated from Gardenia jasminoides on metabolic alterations in high sugar diet-fed rats.

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Abstract
The effects of geniposide isolated from Gardeniae Fructus [used in Chinese medicine as a remedy for inflammation and hepatic disorder] (San-shi-shi) on metabolic alterations in high sugar diet-fed rats were investigated. The oral administration of the high sugar diet caused hyperlipemia, liver injury with elevation of glutamic pyruvic transaminase (GPT) in the serum and the accumulation of lipid peroxide in the liver. Geniposide reduced the serum triglyceride, lipid peroxide, phospholipid, glucose, insulin and GPT in the high sugar diet-fed rats. The administration of geniposide reduced the sucrase activity in the small intestine and the deposition of lipid peroxide in the liver.