The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
- 1 February 1990
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 87 (3) , 928-932
- https://doi.org/10.1073/pnas.87.3.928
Abstract
Serotonin exerts its diverse physiological effects by interacting with multiple distinct receptor subtypes. We have isolated a rat brain 5HT2 serotonin receptor cDNA by virtue of its homology with the 5GT1c receptor. The 5HT2 receptor is a member of the family of receptors that are linked to guanine nucleotide-binding proteins and are predicted to span the lipid bilayer seven times. Overall sequence identity between the 5HT2 and 5HT1c receptors is 49%, but identity within the transmembrane domains is 80%. Expression of both the 5HT2 and 5HT1c receptors in transfected mouse fibroblasts activates phospholipase C signaling pathways and promotes cellular transformation. However, RNA blotting shows that these two receptor subtypes are differentially expressed in the central nervous system. In this manner, structurally and functionally homologous receptor subtypes may elicit distinct physiologic actions.This publication has 29 references indexed in Scilit:
- Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant TransformationScience, 1989
- The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptorNature, 1988
- Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c ReceptorScience, 1988
- The Coupling of Neurotransmitter Receptors to Ion Channels in the BrainScience, 1988
- Construction and Characterization of a Retroviral Vector Demonstrating Efficient Expression of Cloned cDNA SequencesDNA, 1988
- An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteinsNature, 1987
- Identification of a Family of Muscarinic Acetylcholine Receptor GenesScience, 1987
- A family of receptors coupled to guanine nucleotide regulatory proteinsBiochemistry, 1987
- Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsinNature, 1986
- The arrangement and rearrangement of antibody genesNature, 1978