Immunological and biological characteristics of a new TRF analogue, L-pyroglutamyl-L-histidyl-L-pipecolic acid amide.

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Abstract
The immunological and biological potencies of a new synthetic TRF [thyrotropin-releasing factor] analogue, L-pyroglutamyl-L-histidyl-L-pipecolic acid amide, were compared with those of TRF. In a radioimmunoassay system for TRF, parallel inhibition curves were obtained with TRF and the analogue, the immunological potency of the latter being approximately 50% of the former. In vitro and in vivo TSH[thyrotropin]-releasing activities of the analogue were almost equal to those of TRF. As was observed with TRF, the in vitro TSH-releasing effect of the analogue was reduced in the presence of T4 [thyroxine] and the analogue was inactivated by incubation with rat serum. The pyrrolidine ring of TRF can probably be replaced with piperidine ring without significant loss of the biological activity.

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