Efficacy and Acceptability of Tadenan®(Pygeum africanum Extract) in the Treatment of Benign Prostatic Hyperplasia (BPH): A Multicentre Trial in Central Europe

Abstract
SummaryPygeum africanum extract is available as Tadenan ® in many countries, including those in central and eastern Europe, for the treatment of mild to moderate BPH. Its efficacy and acceptability have been demonstrated in numerous open and placebo-controlled studies in large populations. The present open three-centre efficacy and safety study was conducted according to common protocol at urology clinics in the Czech and Slovak Republics and in Poland, in order to confirm the therapeutic profile o/Pygeum africanum in conditions of daily practice, using International Prostate Symptom Score (IPSS) andflowmetry assessments.Men aged 50-75 years and in compliance with the selection criteria (including IPSS ≥ 12, quality of life (QoL) score ≥ 3, and maximum urinary flow ≤ 15 mils) were first examined then recalled after two weeks during which no treatment was provided (washout and check of stability). If still compliant, they were entered at this point into a two-month period of treatment with Pygeum africanum...