Micromolar Calcium Stimulates Proteolysis and Glutamate Binding in Rat Brain Synaptic Membranes
- 22 May 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 212 (4497) , 937-938
- https://doi.org/10.1126/science.7015504
Abstract
Incubation of cortical synaptic membranes with low concentrations of calcium resulted in a decrease in the amount of a high-molecular-weight doublet protein and an increase in the sodium-independent binding of glutamate. Both effects were blocked by the thiol protease inhibitor leupeptin. These results suggest that calcium-induced proteolysis of membrane components regulates the number of glutamate receptors in neuronal membranes.Keywords
This publication has 25 references indexed in Scilit:
- Phospholipid Methylation and Biological Signal TransmissionScience, 1980
- Participation of cystein proteinase in the high affinity ca2+-dependent binding of glutamate to hippocampal synaptic membranesNeuropharmacology, 1980
- Increase in glutamate receptors following repetitive electrical stimulation in hippocampal slicesLife Sciences, 1980
- Hormonal regulation of peptide receptors and target cell responsesNature, 1979
- A CALCIUM ACTIVATED PROTEASE IN SQUID AXOPLASMJournal of Neurochemistry, 1979
- Chemical and structural changes of neurofilaments in transected rat sciatic nerveThe Journal of cell biology, 1978
- Surface Modulation in Cell Recognition and Cell GrowthScience, 1976
- The ß-adrenergic receptor and adenylate cyclaseBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1976
- Neurofilament disguise, destruction and disciplineNature, 1975
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970