Inhibition and enhancement of platelet aggregation by collagen derivatives

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Abstract
Rat tail tendon tropocollagen rapidly caused the aggregation of blood platelets coincident with collagen multimerization. Several long‐chain alkyl derivatives of collagen, however, were completely unable to induce platelet aggregation even at unusually high concentrations. These collagen derivatives varied in their polymerization properties, and the polymerization of tropocollagen derivatives was shown not necessarily to be a prerequisite for platelet aggregation. These collagen derivatives may enhance the antithrombogenic properties of collagenbased prostheses. A short‐chain derivative, collagen‐glycine ethyl ester, profoundly enhanced platelet aggregation in the absence of any measurable polymerization. This derivative may be useful as a growth‐promoting burn dressing.

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