The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs
- 1 November 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 342 (6249) , 512-518
- https://doi.org/10.1038/342512a0
Abstract
The c-mos proto-oncogene product, pp39mos, is present in unfertilized Xenopus eggs, and disappears on fertilization. Microinjection of synthetic mos RNA into two-cell embryos induces cleavage arrest at metaphase. By contrast, egg cytosol extracts, when immunodepleted of endogenous pp39mos, lose their cleavage-arresting activity in injected embryos. These results demonstrate that Mos protein is the cytostatic factor CSF, long known as an endogenous meiotic inhibitor in vertebrate eggs.Keywords
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