Sensitivity of Bacteria to NaNO2 and to L‐Arginine‐Dependent System in Murine Macrophages
- 1 April 1991
- journal article
- Published by Wiley in Microbiology and Immunology
- Vol. 35 (4) , 325-329
- https://doi.org/10.1111/j.1348-0421.1991.tb01561.x
Abstract
Sensitivity of bacteria to NO2-/NO and to L-arginine-dependent system in murine macrophages was tested. The growth of all bacteria tested, Salmonella typhimurium, Pseudomonas aeruginosa and Staphylococcus epidermidis, was significantly inhibited by NaNO2 at the concentration of 5 to 10 mM. However, L-arginine-dependent effector mechanism of LPS-activated murine macrophages was ineffective in killing these bacteria. It seems that the concentration of NO2-/NO in phagolysosome in the activated macrophages is insufficient to kill the bacteria in situ. We concluded that L-arginine-dependent effector mechanism can hardly work on bacteria killing in activated macrophages.Keywords
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