Microscopy of Synapses of Non-Excised Frog Heart

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Abstract
The synapses of beating, non-excised frog heart are amenable to microscopy with the vagi intact, and reveal a number of differences from the synapses of beating heart which has been excised. The terminals and end-feet of the vagi, and the ganglion cells on which they impinge, can be observed to pass through two stages of morphologic deterioration. The vagal effect can be produced until the second stage predominates in the preparation. Synaptic transmission from tetanization of the vagus is followed by visible changes in both the pre- and the postsynaptic structures.

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