EFFECT OF A SINGLE GLYCOCORTICOID INJECTION ON THE FIRST DAY OF LIFE IN RATS
- 1 January 1966
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 51 (1) , 71-76
- https://doi.org/10.1530/acta.0.0510071
Abstract
A single large dose of glycocorticoid injected in the rat on the first day of life produces a fatal cachectic condition which is very similar to the wasting syndrome which follows post-neonatal thymectomy. After smaller doses the survival time is longer and the mortality rate is less. Body weights, weights of thymus, spleen and adrenals are lower in treated rats than in non-treated control littermates. So is the number of small lymphocytes in the peripheral blood and in the lymphoid organs.This publication has 7 references indexed in Scilit:
- Wasting Disease Induced in Young Mice by Administration of Cortisol AcetateScience, 1964
- Evidence for Function of Thymic Tissue in Diffusion Chambers Implanted in Neonatally Thymectomized Mice. Preliminary ReportJNCI Journal of the National Cancer Institute, 1963
- THE ROLE OF THE THYMUS IN DEVELOPMENT OF IMMUNOLOGIC CAPACITY IN RABBITS AND MICEThe Journal of Experimental Medicine, 1962
- Effect of neonatal thymectomy on the immunological responsiveness of the mouseProceedings of the Royal Society of London. B. Biological Sciences, 1962
- ROLE OF THE THYMUS IN IMMUNE REACTIONS IN RATSThe Journal of Experimental Medicine, 1962
- Role of the Thymus in Neonatal LifeNature, 1962
- THE THYMIC LYMPHOCYTOSIS‐STIMULATING FACTORAnnals of the New York Academy of Sciences, 1958