Calcium and lipid peroxidation in mitochondrial and microsomal membranes of the heart

Publisher Website
Google Scholar
Abstract
The effect of lipid peroxidation [in rats] (LP) on Ca2+-transport and the effect of different Ca2+-concentrations on the LP activation were studied in microsomes and mitochondria of the heart. A slight accumulation of LP-products in the microsomal fraction results in a complete inhibition of the membrane Ca-transport activity. Preliminary administration of antioxidants (4-methyl 2,6-ditertbutylphenol and .alpha.-tocopherol) prevents both the accumulation of LP-products and damage of the Ca2+-transport system. Ca at 10-6 M to 5 .cntdot. 10-5 M concentrations stimulates LP and while being increased to 2 .cntdot. 10-3 M it inhibits LP. The data obtained evidence an interrelation between alterations of the Ca2+-concentrations and LP activation in cardiomyocytes.