Bioactive Polymers XXXVI. Controlled Release of Cephalosporine C from Cellulosic Derivatives
- 1 July 1986
- journal article
- Published by SAGE Publications in Journal of Bioactive and Compatible Polymers
- Vol. 1 (3) , 285-300
- https://doi.org/10.1177/088391158600100301
Abstract
Cephalosporine C was coupled onto cellulosic derivatives of N-(4-carboxy phenyl)carbamoylmethyl cellulose and crosslinked carboxymethyl cellulose to achieve controlled drug release. Starting from a mathematical model, the in fluence of certain parameters of the reaction (drug/support, activator/support molecular ratios, and reaction times) on the amount of Cephalosporine C chem ically bound to the cellulose products was determined. Evaluation of the cou pled products show extended activity by the release of Cephalosporine C by hydrolysis.Keywords
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