DEXTRAN SULFATE STIMULATES THE INDUCTION BUT INHIBITS THE EFFECTOR PHASE IN T CELL-MEDIATED CYTOTOXICITY

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Abstract
To resolve to what extent [mouse] T [thymus-derived] cell functions are affected by dextran sulfate [DS], T cell-mediated cellular cytotoxicity against the allogeneic [mouse] DBA/2 mastocytoma was examined. Under the influence of DS, the development of cellular cytotoxicity is delayed, but finally the cytotoxicity exceeds the control values and persists at a time when the control response has decreased. The kinetics could be explained by DS extending the proliferation time of cytotoxic cell precursors and delaying the appearance of cytotoxic effector cells. This would allow a clonal expansion of cytotoxic T cells. In contrast to its stimulating capacity during the induction phase, DS inhibits the effector phase of cytotoxic T cells.

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