A comparison of test methods in influenza chemotherapy

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Abstract
The anti-influenzal activity of ribavirin and amantadine hydrochloride has been compared in different test systems. Strains belonging to the four A sub-types H0N1, H1N1, H2N2 and H3N2 were employed. Although some variation was found between systems, the four strains were found to be of similar sensitivity to ribavirin, the inhibitory activity of which differed very little from that of amantadine hydrochloride with the more recent strains. In mice the sensitivity of the strains to the two compounds appeared to decrease with increasing passage in the mouse lung up to the 30th passage level. It is suggested that ribavirin should be used as a tool to check that viruses are similarly adapted to mice, particularly for strains which are not very sensitive to amantadine hydrochloride.

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