Editorial Response: Discordance between Virological, Immunologic, and Clinical Outcomes of Therapy with Protease Inhibitors among Human Immunodeficiency Virus-Infected Patients

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Abstract
In this issue of Clinical Infectious Diseases, Mezzaroma et al. [1] describe the occurrence of discordant virological and immunologic responses among 77 HIV-infected patients who had received 24 months of protease inhibitor-based antiretroviral therapy. These patients had begun to receive this therapy when their CD4+ lymphocyte counts were 1.0 log10 and increases in CD4+ cell counts of >50 cells/µL, were observed in 29 patients (group I). Thirty-two other patients had only an immunologic response (group II), and 10 patients had neither immunologic nor virological responses (group III). Six patients were lost to follow-up.