Dietary intake and risk evaluation of polybrominated diphenyl ethers in The Netherlands
- 1 February 2008
- journal article
- research article
- Published by Wiley in Molecular Nutrition & Food Research
- Vol. 52 (2) , 204-216
- https://doi.org/10.1002/mnfr.200700112
Abstract
The current study aims at estimating the dietary intake of PBDEs in the Netherlands and evaluating the resultant risk. Dietary intake was estimated using results of PBDE analyses in Dutch food products from 2003/2004 and consumption data of the third Dutch National Food Consumption Survey (1997/1998). Assuming that non‐detects represent levels of half the detection limit, the median long‐term intake of the Dutch population of the sum of five major PBDEs (namely PBDEs 47, 99, 100, 153+154) is 0.79 ng/kg body weight bw/day (P97.5: 1.62 ng/kg bw/day). When non‐detects are considered as zeros the values are 0.53 (median) and 1.34 (P97.5) ng/kg bw/day. Environmental concentrations of PBDEs in Europe are expected to decline in the near future because of the ban on penta‐ and octaBDE technical products. However, it will take at least a decade before this will result in lower PBDE concentrations in food products. Hence, a regular monitoring program for PBDEs is recommended. A risk evaluation at the most sensitive endpoints of BDE 99 carried out in this paper indicates that, although the long‐term exposure to BDE 99 is well below the human exposure threshold level for neurodevelopmental toxicity, it may be close to that for reproductive toxicity.Keywords
This publication has 39 references indexed in Scilit:
- Neonatal Exposure to Higher Brominated Diphenyl Ethers, Hepta-, Octa-, or Nonabromodiphenyl Ether, Impairs Spontaneous Behavior and Learning and Memory Functions of Adult MiceToxicological Sciences, 2006
- Dose-Response Modeling and Benchmark Calculations from Spontaneous Behavior Data on Mice Neonatally Exposed to 2,2',4,4',5-Pentabromodiphenyl EtherToxicological Sciences, 2004
- Reduced intake of deoxynivalenol in The Netherlands: a risk assessment updateToxicology Letters, 2004
- Polybrominated diphenyl ethers (PBDEs) and their methoxylated derivatives in pike from Swedish waters with emphasis on temporal trends, 1967–2000Environmental Pollution, 2004
- Brominated flame retardants: cause for concern?Environmental Health Perspectives, 2004
- Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult miceToxicology and Applied Pharmacology, 2003
- Neurobehavioral Derangements in Adult Mice Receiving Decabrominated Diphenyl Ether (PBDE 209) during a Defined Period of Neonatal Brain DevelopmentToxicological Sciences, 2003
- Maternal Exposure to a Low Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Suppressed the Development of Reproductive Organs of Male Rats: Dose-Dependent Increase of mRNA Levels of 5 -Reductase Type 2 in Contrast to Decrease of Androgen Receptor in the Pubertal Ventral ProstateToxicological Sciences, 2001
- Interindividual Variability in Modeling Exposure and Toxicokinetics: A Case Study on Cadmium.Environmental Health Perspectives, 1994
- Modeling Long‐Term Exposure of the Whole Population to Chemicals in FoodRisk Analysis, 1993