Neuromuscular blocking effects of certain antibacterial agents in pigs and lambs
- 1 June 1978
- journal article
- Published by Wiley in Journal of Veterinary Pharmacology and Therapeutics
- Vol. 1 (2) , 171-175
- https://doi.org/10.1111/j.1365-2885.1978.tb00322.x
Abstract
The neuromuscular blocking effects of several antibacterial agents were examined in young pigs and lambs using a sciatic nerve‐gastrocnemius muscle preparation. Intravenous administration of streptomycin, neomycin or tetracycline produced a decrease in indirectly stimulated contractions of the gastrocnemius muscle; whereas, chloramphenicol, sulphadiazine and penicillin‐G had no discernible neuromuscular blocking effects. Present findings confirm the neuromuscular blocking activity of certain antibiotic agents, and indicate the potential for this adverse side effect in food‐producing animal species.Keywords
This publication has 2 references indexed in Scilit:
- Neuromuscular Blocking Effects of Aminoglycoside Antibiotics on Fast- and Slow-Contracting Muscles of the CatAnesthesia & Analgesia, 1976
- Antibiotic Blockade of Neuromuscular FunctionAnnual Review of Pharmacology, 1972