Syntheses of the First Endothelin-A- and -B-Selective Radioligands for Positron Emission Tomography
- 1 January 2000
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 36 (5) , S58-S60
- https://doi.org/10.1097/00005344-200036001-00020
Abstract
We have synthesized two potential positron emission tomography (PET) radioligands for the endothelin (ET) receptor. ‘11C’-PD156707 was produced by O-methylation of PD169390 using ‘11C’iodomethane. Radiochemical conversions of the order of 74± 3.2% (n=8) were obtained. The radiochemical purity of the isolated [11C]-PD156707 was 99% and the specific activity was 538mCi/μmol.[18F]-BQ3020 was produced from [18]fluoride in a total radiochemical yield of 2.7 ± 0.4% (n=10) in 238 ± 5 min. The radiochemical purity was 95% and specific activities of the order of 670-930 mCi/μmol were obtained.Keywords
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