Estrogen Plus Progestin and Risk of Venous Thrombosis
Top Cited Papers
Open Access
- 6 October 2004
- journal article
- clinical trial
- Published by American Medical Association (AMA) in JAMA
- Vol. 292 (13) , 1573-1580
- https://doi.org/10.1001/jama.292.13.1573
Abstract
Venous thrombosis (VT), including deep vein thrombosis (DVT) and pulmonary embolus (PE), is a common disorder with an incidence of about 1 to 2 per 1000 person-years among adults.1 The risk of VT is higher with older age, in men compared with women, in blacks compared with whites, and in obese individuals, but VT is generally not associated with other classic atherogenic risk factors.2-4 Postmenopausal hormone therapy, such as estrogen with or without progestin, and selective estrogen-receptor modulators (tamoxifen and raloxifene) are associated with a 2- to 3-fold increased risk of VT.5-7Keywords
This publication has 18 references indexed in Scilit:
- The Epidemiology of Venous ThromboembolismCirculation, 2003
- Obesity: risk of venous thrombosis and the interaction with coagulation factor levels and oral contraceptive useThrombosis and Haemostasis, 2003
- Factor V Leiden, Hormone Replacement Therapy, and Risk of Venous Thromboembolic Events in Women With Coronary DiseaseArteriosclerosis, Thrombosis, and Vascular Biology, 2002
- Female Hormones and ThrombosisArteriosclerosis, Thrombosis, and Vascular Biology, 2002
- Postmenopausal Hormone Therapy Increases Risk for Venous Thromboembolic Disease: The Heart and Estrogen/progestin Replacement StudyAnnals of Internal Medicine, 2000
- Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 StudyJNCI Journal of the National Cancer Institute, 1998
- Hormone replacement therapy and risk of venous thromboembolism: population based case-control studyBMJ, 1997
- Risk of hospital admission for idiopathic venous thromboembolism among users of postmenopausal oestrogensThe Lancet, 1996
- Risk of venous thromboembolism in users of hormone replacement therapyThe Lancet, 1996
- Prospective study of exogenous hormones and risk of pulmonary embolism in womenThe Lancet, 1996