HPLC Analysis of Toxic Additives and Residual Monomer from Dental Plate

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Abstract
Methyl methacrylate polymer, polysulphone, polycarbonate and CleafilR are widely used as the dental plate. During fabrication, there is a potential for toxic compound residue of methyl methacrylate, N,N-dimethyl p-toluidine, benzoylperoxide, benzoic acid, bisphenol A, 4,4′-dichlorodiphenylsulfone, triethyleneglycol dimethacrylate and bis phenol A diglycidylmethacrylate. This raises a safety concern as these compounds exhibit carcinogenicity and mutagenicity. The elution of these compounds to water, organic solvents and serum is determined to evaluate a risk to the patients. Analysis is by HPLC using a newly developed and sufficiently endocapped ODS column combined with UV detection. The eluted amount is generally proportional to the hydrophobicity of the organic solvent. Serum extracts hydrophilic compounds as well as hydrophobic compounds. Risk to the patients exposed by these compounds is not so significant.