Mutagenic evaluation of nitroparaffins in the salmonella typhimurium/mammalian‐microsome test and the micronucleus test

Publisher Website
Google Scholar
Abstract
Three nitroparaffins (nitroethane, 1‐nitropropane, and 2‐nitropropane) were studied in the Salmonella typhimurium/mammalian microsome (Ames) test, with and without microsomal activation systems. Nitroethane and 2‐nitropropane also were studied in an in vivo mutagenic (micronucleus) test. These studies were undertaken because these solvents are widely used in the chemical and pharmaceutical industries and 2‐nitropropane was reported to cause liver cancer in rats exposed by the inhalation route.Neither nitroethane nor 1‐nitropropane was active in the Ames test with Salmonella tester‐strains TA1537, TA92, TA98, or TA100. However, 2‐nitropropane produced a significant increase in revertants in all of these tester strains, particularly strain TA100, where 3μl/plate doubled the number of revertants in the presence of microsomal enzymes. Negative results were obtained with both nitroethane and 2‐nitropropane in micronucleus tests. These studies have shown that 2‐nitropropane has the potential for causing point mutations in a microbial test system. However, this compound probably will not cause a chromosome mutation of the clastogenic type.

This publication has 3 references indexed in Scilit: