Neuropeptide Y enhances the inhibitory effects of clonidine on3H-noradrenaline release in synaptosomes isolated from the medulla oblongata of the male rat
- 1 March 1986
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 67 (1-2) , 113-124
- https://doi.org/10.1007/bf01243364
Abstract
In studies on superfused synaptosomes from the rat medulla oblongata, the inhibitory effects of theα2-adrenergic agonist clonidine (0.1μM) on potassium (15 mM K+) induced3H-noradrenaline (NA) release was potentiated by 20%, when neuropeptide Y was added to the system. The effect of NPY was detectable at low concentrations (1 nM) and was not dose-dependent. Neuropeptide Y alone produced no significant effects on3H-NA release. The results may indicate the existence of a presynaptic NPY receptor on the noradrenaline and/or adrenaline nerve terminals, which may enhance the presynapticα2-adrenoreceptor function to inhibit3H-NA release.This publication has 36 references indexed in Scilit:
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